Recent Publications


    Papers in Refereed Journals

  • Dzeja, P.P., P. Bast, C. Ozcan, A. Valverde, E.L. Holmuhamedov, D.G.L. Van Wylen, and A. Terzic. 2003. Targeting nucleotide-requiring enzymes: implications for diazoxide-induced cardioprotection. Am. J. Physiol. 284:H1048-56.

  • Cerniway R.J., R.R. Morrison, A.M. Byford, A.R. Lankford, J.P. Headrick, D.G.L. Van Wylen, and G.P. Matherne. 2002. A1 adenosine receptor overexpression decreases stunning from anoxia-reoxygenation: role of the mitochondrial katp channel. Basic Res. Cardiol. 97:232-238.

  • Mortimer, S.L., C.T. Kodl, C.R. Reiling and D.G.L. Van Wylen. 2000. Preconditioning-induced attenuation of purine metabolite accumulation during repetitive ischemia: memory and multiple cycles. Basic Res. Cardiol. 95:119-126.

  • Thourani, V.H., R.S. Ronson, D.G.L. Van Wylen, S.T. Schearer, S.L Katzmark, Z.Q. Zhao, D.C. Han, R.A. Guyton and J. Vinten-Johansen. 1999. Adenosine-supplemented blood cardioplegia attenuates postischemic dysfunction after severe regional ischemia. Circulation 100 (Suppl II):II-376-II383.

  • Ichord, R.N., F.J. Northington, D.G.L. Van Wylen, M.V. Johnston, C. Kwon and R.J. Traystman. 1999. Brain O2 consumption and glutamate release during hypoglycemic coma in piglets are temperature sensitive. Am. J. Physiol. 276:H2053-H2062.

  • Grabb, M.C., V.M. Sciotti, S.A. Cohen and D.G.L. Van Wylen. 1998. Altered physiological and morphological responses with chronically implanted brain microdialysis probes. J. Neurosci. Meth. 82:25-34.

  • Manthei, S.A., C.R. Reiling and D.G.L. Van Wylen. 1998. Dual cardiac microdialysis to assess drug-induced changes in interstitial purine metabolites: adenosine deaminase inhibition versus adenosine kinase inhibition. Cardiovasc. Res. 37:171-178.

  • Manthei, S.A. and D.G.L. Van Wylen. 1997. Purine Metabolite Accumulation During Myocardial Ischemia: Adenosine Versus Ischemic Preconditioning. Basic Res. Cardiol. 92:368-377.

  • Martin, B.J., T.B. McClanahan, D.G.L. Van Wylen and K.P. Gallagher. 1997. Effects of ischemia, preconditioning, and adenosine deaminase inhibition on interstitial fluid adenosine levels and infarct size. Basic Res. Cardiol. 92:240-251.

  • Todd, J., Z. Zhao, M.W. Williams, H. Sato, D.G.L. Van Wylen and J. Vinten-Johansen. 1996. Intravascular adenosine at reperfusion reduces infarct size and neutrophil adherence. Ann. Thorac. Surg. 62:1364-1372.

  • Goto, M., M.V. Cohen, D.G.L. Van Wylen and J.M. Downey. 1996. Attenuated purine production during subsequent ischemia in the preconditioned rabbit myocardium is unrelated to the mechanism of protection. J. Mol. Cell. Cardiol. 28:447-454.

  • Hall, J.L., D.G.L. Van Wylen, R.D. Pizzurro, C.D. Hamilton, C.M. Reiling and W.C. Stanley. Myocardial interstitial purine metabolites and lactate with increased work in swine. Cardiovasc. Res. 30:351-356.

  • Cohen, M.V., K.S. Snell, A. Tsuchida, D.G.L. Van Wylen and J.M. Downey. 1995. Effects of anesthesia and K+ATP channel blockade on interstitial adenosine accumulation in ischemic rabbit myocardium. Basic Res. Cardiol. 90:410-417.

  • Silva, P.H., D. Dillon and D.G.L. Van Wylen. 1995. Adenosine deaminase inhibition augments interstitial adenosine but does not attenuate myocardial infarction. Cardiovasc. Res. 29:616-623.

  • Zhao, Z., M.W. Williams, H. Sato, D.A. Hudspeth, B.S. McGee, J. Vinten-Johansen and D.G.L. Van Wylen. 1995. Acadesine reduces infarct size by an adenosine-mediated process without augmenting interstitial adenosine levels. Cardiovasc. Res. 29:495-505.


    Book Chapters

  • Van Wylen, D.G.L. 1996. Assessment of interstitial fluid adenosine: implications for exogenous and endogenous adenosine-mediated cardioprotection. In Purines and Myocardial Protection, Kluwer Academic Publishers, Inc.


    Abstracts from Conference Proceedings

  • Kelly, C.R., M.C. Miller, P.H. Bast, A.C. Cambray and D.G.L. Van Wylen. 2000. Threshold ischemic stimulus for attenuation of purine metabolite accumulation during serial brief ischemia. FASEB J. 14:A425.

  • Thourani, V.H., R.S. Ronson, D.G.L. Van Wylen, S.T. Schearer, S.L Katzmark, Z.Q. Zhao, R.A. Guyton and J. Vinten-Johansen. 1998. Myocardial protection with adenosine given at reperfusion is superior to adenosine-enriched cardioplegia. Circulation 98:I-612.

  • Kodl, C.T., S.M. Martimer, C.M. Reiling and D.G.L. Van Wylen. 1998. Preconditioning-induced attenuation of purine metabolite accumulation during ischemia (ISC): memory and multiple cycles. FASEB J. 12:A1114.

  • Cambray, A.J., C.M. Reiling and D.G.L. Van Wylen. 1998. Intersitital fluid (ISF) adenosine during exogenous adenosine administration in the isolated rabbit heart. FASEB J. 12:A76.

  • Reiling C.M. and D.G.L. Van Wylen. 1998. Changes in interstitial fluid (ISF) K+ during myocardial ischemia (ISC) and reperfusion (REP) in the rabbit. FASEB J. 12:A77.

  • Rood, K.L., C.M. Reiling and D.G.L. Van Wylen. 1998. Exogenous adenosine does not prevent attenuted purine metabolite production during repeated ischemia (ISC). FASEB J. 12:A76.

  • Van Wylen, D.G.L. 1997. Adenosine and preconditioning. J. Mol. Cell. Cardiol. 29:A272.

  • Manthei, S.A., C.M. Reiling and D.G.L. Van Wylen. 1996. Dual cardiac microdialysis to assess drug-induced changes in interstitial fluid (ISF) adenosine (ADO) during ischemia (ISC): adenosine deaminase (ADA) versus adenosine kinase. FASEB J. 10:A11.

  • Reiling, C.M., D.J. Mumm and D.G.L. Van Wylen. 1996. Ischemic preconditioning (PC) with and without inhibition of adenosine (ADO) deaminase. FASEB J. 10:A11.

  • Zimmer, C.M., C.M. Reiling and D.G.L. Van Wylen. 1996. Graded attenuation of purine metabolite accumulation during ischemia (ISC) dependent upon duration of preconditioning. FASEB J. 10:A12.

  • Todd, J., Z. Zhao, H. Sato, M. Williams, J. Vinten-Johansen and D.G.L. Van Wylen. 1995. Adenosine-induced cardiac protection during reperfusion is mediated by intravascular A2 receptor activation. Circulation 92:I-524.

  • Vinten-Johansen, J., H. Sato, Z. Zhao and D.G.L. Van Wylen. 1995. Controlled hydrodynamics of reperfusion reduces infarct size independent of delayed washout of interstitial adenosine or attenuated neutrophil accumulation in the area at risk. Circulation 92: I-458, 1995.

  • Ichord, R., M.A. Halfaer, F.J. Northington, D.G.L. Van Wylen and R.J. Traystman. 1995. Excessive glutamate efflux coincides with cerebral hyperemia and increased cerebral oxygen consumption during hypoglycemic coma in piglets. FASEB J. 9: A259.