Synthesis Ideas

Notice to Authors Target Compounds A-E
And here are the results. Congratulations to all successful authors!

	a-mg.htm	Comments:Several other excellent syntheses were received, but only this one is of the correct compound! Honorable mention (and credit) goes to: a-njhale.htm a-pc.htm a-rsthkr.htm
	b-aspsvh.htm b-bc.htm b-jgrhab.htm b-mg.htm b-njhale.htm	Comments:Note how most of these syntheses avoid regioselectivity issues by avoiding addition to internal alkenes or alkynes.
	c-aspsvh.htm c-bc.htm c-jgabrh.htm c-mg.htm c-njhale.htm c-prmsmd.htm c-rsthkr.htm	Comments:Note how five of these seven syntheses nicely avoid regioselectivity issues by generating the trans-alkene from the alkyne instead of doing an elimination. There is some question whether the dianion from an acetylenic alcohol will be alkylated at C or O, but that just makes some of these proposals more interesting!
	d-njhale.htm d-pc.htm d-rsthkr.htm d-rvhg.htm	Comments:Of these syntheses, the first three are quite plausible. The last might have some compatibility issues. Again, will the dianion of an acetylenic alcohol alkylate on C or O?
	e-njhale.htm e-pc.htm e-rsthkr.htm	Comments: All of these suffer from regioselectivity problems associated with the tri-substituted double bond. This is a very difficult problem in organic synthesis.