Synthesis of Compound B
  • Using Magnesium with Tetrahydrafurian (THF), using a ketone to add onto the carbon chain.
  • The hydroxyl group was replaced by bromine using PBr3 
  • Mg/THF was again utilized to add the final 2 carbons to the product.
  • The hydrogen on the hydroxyl group is replaced by tosyl, which acts as a great leaving group.
  • Elimanation of the TsO- creates a double bond, and for our purposes the Zaitseff or Hoffman product will eventually lead to the product
  • Hydrogen on activated Platinum creates the desired alkane.

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