Synthesis of Compound C
  • First react with Magnesium in Tetrahydrafurian (THF), and then use a ketone to add three carbons to the chain..
  • The hydroxyl group was replaced by bromine using PBr3 
  • Then Na makes an alkyne anion, and adds an alkyl bromide.
  • Lithium in ammonia forms the trans product.
  • PBr3 replaces the hydroxyl group.
  • Mg in THF and then water replaces bromine with hydrogen.

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